Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide en es it fr

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Brand names, Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Analogs

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Brand Names Mixture

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Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Chemical_Formula


Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide RX_link


Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide fda sheet

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide msds (material safety sheet)

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Synthesis Reference

No information avaliable

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Molecular Weight

331.294 g/mol

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Melting Point

272 - 273 oC

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide H2O Solubility

No information avaliable

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide State


Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide LogP


Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Dosage Forms


Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Indication

Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Pharmacology

Hydroflumethiazide is an oral thiazide used to treat hypertension and edema. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. Like other thiazides, Hydroflumethiazide promotes water loss from the body (diuretics). Thiazides inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Absorption

Hydroflumethiazide is incompletely but fairly rapidly absorbed from the gastrointestinal tract

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide side effects and Toxicity

Overdoses lead to diuresis, lethargy progressing to coma, with minimal cardiorespiratory depression and with or without significant serum electrolyte changes or dehydration.

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Patient Information

Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide Organisms Affected

Humans and other mammals