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Spandiuril Brand names, Spandiuril Analogs

Spandiuril Brand Names Mixture

  • No information avaliable

Spandiuril Chemical_Formula


Spandiuril RX_link

Spandiuril fda sheet

Spandiuril msds (material safety sheet)

Spandiuril Synthesis Reference

No information avaliable

Spandiuril Molecular Weight

331.294 g/mol

Spandiuril Melting Point

272 - 273 oC

Spandiuril H2O Solubility

No information avaliable

Spandiuril State


Spandiuril LogP


Spandiuril Dosage Forms


Spandiuril Indication

Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Spandiuril Pharmacology

Hydroflumethiazide is an oral thiazide used to treat hypertension and edema. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. Like other thiazides, Hydroflumethiazide promotes water loss from the body (diuretics). Thiazides inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Spandiuril Absorption

Hydroflumethiazide is incompletely but fairly rapidly absorbed from the gastrointestinal tract

Spandiuril side effects and Toxicity

Overdoses lead to diuresis, lethargy progressing to coma, with minimal cardiorespiratory depression and with or without significant serum electrolyte changes or dehydration.

Spandiuril Patient Information

Spandiuril Organisms Affected

Humans and other mammals