Hydroflumethazide en es it fr

Hydroflumethazide Brand names, Hydroflumethazide Analogs

Hydroflumethazide Brand Names Mixture

  • No information avaliable

Hydroflumethazide Chemical_Formula


Hydroflumethazide RX_link


Hydroflumethazide fda sheet

Hydroflumethazide msds (material safety sheet)

Hydroflumethazide Synthesis Reference

No information avaliable

Hydroflumethazide Molecular Weight

331.294 g/mol

Hydroflumethazide Melting Point

272 - 273 oC

Hydroflumethazide H2O Solubility

No information avaliable

Hydroflumethazide State


Hydroflumethazide LogP


Hydroflumethazide Dosage Forms


Hydroflumethazide Indication

Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Hydroflumethazide Pharmacology

Hydroflumethiazide is an oral thiazide used to treat hypertension and edema. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. Like other thiazides, Hydroflumethiazide promotes water loss from the body (diuretics). Thiazides inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Hydroflumethazide Absorption

Hydroflumethiazide is incompletely but fairly rapidly absorbed from the gastrointestinal tract

Hydroflumethazide side effects and Toxicity

Overdoses lead to diuresis, lethargy progressing to coma, with minimal cardiorespiratory depression and with or without significant serum electrolyte changes or dehydration.

Hydroflumethazide Patient Information

Hydroflumethazide Organisms Affected

Humans and other mammals