Torsemide
Torsemide Brand names, Torsemide Analogs
Torsemide Brand Names Mixture
- No information avaliable
Torsemide Chemical_Formula
C16H20N4O3S
Torsemide RX_link
http://www.rxlist.com/cgi/generic/demadex.htm
Torsemide fda sheet
Torsemide msds (material safety sheet)
Torsemide Synthesis Reference
No information avaliable
Torsemide Molecular Weight
348.421 g/mol
Torsemide Melting Point
164-164 oC
Torsemide H2O Solubility
Water soluble
Torsemide State
Solid
Torsemide LogP
2.404
Torsemide Dosage Forms
Liquid; Tablet
Torsemide Indication
For the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Torsemide Pharmacology
Torsemide is a novel loop diuretic belonging to pridine sulphonyl urea. It differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Like thiazides, loop diuretics must be secreted into the tubular fluid by proximal tubule cells. In the thick ascending loop Na+ and Cl- reabsorption is accomplished by a Na+/K+/2Cl- symporter. The thick ascending limb has a high reabsorptive capacity and is responsible for reabsorbing 25% of the filtered load of Na+. The loop diuretics act by blocking this symporter. Because of the large absorptive capacity and the amount of Na+ delivered to the ascending limb, loop diuretics have a profound diuretic action. In addition, more distal nephron segments do not have the reabsorptive capacity to compensate for this increased load. The osmotic gradient for water reabsorption is also reduced resulting in an increase in the amount of water excreted.
Torsemide Absorption
Rapidly absorbed following oral administration. Absolute bioavailability is 80%. Food has no effect on absorption.
Torsemide side effects and Toxicity
Symptoms of overdose include dehydration, hypovolemia, hypotension, hyponatremia, hypokalemia, hypochloremic alkalosis, and hemoconcentration. Oral LD50 in rat is 5 g/kg, and intravenous LD50 in rat is 500 mg/kg.
Torsemide Patient Information
Take this medication by mouth with or without food, usually once a day, or as directed by your doctor. The dosage is based on your medical condition and response to therapy. It is best to take this medication early in the day, before 4-6PM, to prevent having to wake up during the night to urinate. Consult your doctor or pharmacist if you have questions about your dosing schedule. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day as directed. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Generally, it may take 4-6 weeks, sometimes up to 12 weeks, before the full blood pressure-lowering effect is seen. Do not stop taking this medication without consulting your doctor. Cholestyramine and colestipol can decrease the absorption of torsemide. If you are taking either of these drugs, separate it from torsemide by at least 2 hours. If your condition persists or worsens, contact your doctor or pharmacist.
Torsemide Organisms Affected
Humans and other mammals
