Torasemide

Torasemide Brand names, Torasemide Analogs

Torasemide Brand Names Mixture

No information avaliable

Torasemide Chemical_Formula

C₁₆H₂₀N₄O₃S

Torasemide RX_link

http://www.rxlist.com/cgi/generic/demadex.htm

Torasemide fda sheet

Torasemide msds (material safety sheet)

Torasemide MSDS

Torasemide Synthesis Reference

No information avaliable

Torasemide Molecular Weight

348.421 g/mol

Torasemide Melting Point

163-164 ^oC (decomposition)

Torasemide H₂O Solubility

Soluble

Torasemide State

Solid

Torasemide LogP

2.404

Torasemide Dosage Forms

Liquid; Tablet

Torasemide Indication

For the treatment of hypertension, edema induced by congestive heart failure or renal disease, and ascites associated with hepatic disease.

Torasemide Pharmacology

Torasemide, a monosulfonamyl loop diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Torasemide is used alone or with atenolol in the management of hypertension and edema. Micropuncture studies in animals have shown that torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na⁺/K⁺/2Cl^--carrier system.

Torasemide Absorption

Bioavailability is approximately 80%. Serum concentration peaks after approximately 1 hour.

Torasemide side effects and Toxicity

LD₅₀ = 5 g/kg (rat, oral), 500 mg/kg (rat, intravenous). Side effects include dizziness, headache, nausea and vomiting.

Torasemide Patient Information