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Toremifene Brand names, Toremifene Analogs

Toremifene Brand Names Mixture

  • No information avaliable

Toremifene Chemical_Formula


Toremifene RX_link

Toremifene fda sheet

Toremifene msds (material safety sheet)

Toremifene Synthesis Reference

R. J. Toivola et al., Eur. pat. Appl. 95,875; U.S. pat. 4,696,949 (1983, 1087 both to Farmos)

Toremifene Molecular Weight

405.959 g/mol

Toremifene Melting Point

108-110 oC

Toremifene H2O Solubility

No information avaliable

Toremifene State


Toremifene LogP


Toremifene Dosage Forms


Toremifene Indication

For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors

Toremifene Pharmacology

Toremifene is an antineoplastic hormonal agent primarily used in the treatment of advanced breast cancer. Toremifene is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Toremifene inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, Toremifene appears to exert its antitumor effects by binding the estrogen receptors. In cytosols derived from human breast adenocarcinomas, Toremifene competes with estradiol for estrogen receptor protein.

Toremifene Absorption

Well absorbed

Toremifene side effects and Toxicity

No information avaliable

Toremifene Patient Information

Patient Information:

Vaginal bleeding has been reported in patients using Toremifene. Patients should be informed about
this and instructed to contact their physician if such bleeding occurs.

Patients with bone metastases should be informed about the typical signs and symptoms of hypercalcemia
and instructed to contact their physician for further assessment if such signs or symptoms occur.

Toremifene Organisms Affected

Humans and other mammals