Fareston
Fareston Brand names, Fareston Analogs
Fareston Brand Names Mixture
- No information avaliable
Fareston Chemical_Formula
C26H28ClNO
Fareston RX_link
http://www.rxlist.com/cgi/generic2/toremifene.htm
Fareston fda sheet
Fareston msds (material safety sheet)
Fareston Synthesis Reference
R. J. Toivola et al., Eur. pat. Appl. 95,875; U.S. pat. 4,696,949 (1983, 1087 both to Farmos)
Fareston Molecular Weight
405.959 g/mol
Fareston Melting Point
108-110 oC
Fareston H2O Solubility
No information avaliable
Fareston State
Solid
Fareston LogP
6.725
Fareston Dosage Forms
Tablet
Fareston Indication
For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors
Fareston Pharmacology
Toremifene is an antineoplastic hormonal agent primarily used in the treatment of advanced breast cancer. Toremifene is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Toremifene inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, Toremifene appears to exert its antitumor effects by binding the estrogen receptors. In cytosols derived from human breast adenocarcinomas, Toremifene competes with estradiol for estrogen receptor protein.
Fareston Absorption
Well absorbed
Fareston side effects and Toxicity
No information avaliable
Fareston Patient Information
Patient Information:
Vaginal bleeding has been reported in patients using Toremifene. Patients should be informed about
this and instructed to contact their physician if such bleeding occurs.
Patients with bone metastases should be informed about the typical signs and symptoms of hypercalcemia
and instructed to contact their physician for further assessment if such signs or symptoms occur.
Vaginal bleeding has been reported in patients using Toremifene. Patients should be informed about
this and instructed to contact their physician if such bleeding occurs.
Patients with bone metastases should be informed about the typical signs and symptoms of hypercalcemia
and instructed to contact their physician for further assessment if such signs or symptoms occur.
Fareston Organisms Affected
Humans and other mammals
