Toremifene Base en es it fr

Toremifene Base Brand names, Toremifene Base Analogs

Toremifene Base Brand Names Mixture

  • No information avaliable

Toremifene Base Chemical_Formula


Toremifene Base RX_link

Toremifene Base fda sheet

Toremifene Base msds (material safety sheet)

Toremifene Base Synthesis Reference

R. J. Toivola et al., Eur. pat. Appl. 95,875; U.S. pat. 4,696,949 (1983, 1087 both to Farmos)

Toremifene Base Molecular Weight

405.959 g/mol

Toremifene Base Melting Point

108-110 oC

Toremifene Base H2O Solubility

No information avaliable

Toremifene Base State


Toremifene Base LogP


Toremifene Base Dosage Forms


Toremifene Base Indication

For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors

Toremifene Base Pharmacology

Toremifene is an antineoplastic hormonal agent primarily used in the treatment of advanced breast cancer. Toremifene is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Toremifene inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, Toremifene appears to exert its antitumor effects by binding the estrogen receptors. In cytosols derived from human breast adenocarcinomas, Toremifene competes with estradiol for estrogen receptor protein.

Toremifene Base Absorption

Well absorbed

Toremifene Base side effects and Toxicity

No information avaliable

Toremifene Base Patient Information

Patient Information:

Vaginal bleeding has been reported in patients using Toremifene. Patients should be informed about
this and instructed to contact their physician if such bleeding occurs.

Patients with bone metastases should be informed about the typical signs and symptoms of hypercalcemia
and instructed to contact their physician for further assessment if such signs or symptoms occur.

Toremifene Base Organisms Affected

Humans and other mammals