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Acapodene Brand names, Acapodene Analogs

Acapodene Brand Names Mixture

  • No information avaliable

Acapodene Chemical_Formula


Acapodene RX_link

Acapodene fda sheet

Acapodene msds (material safety sheet)

Acapodene Synthesis Reference

R. J. Toivola et al., Eur. pat. Appl. 95,875; U.S. pat. 4,696,949 (1983, 1087 both to Farmos)

Acapodene Molecular Weight

405.959 g/mol

Acapodene Melting Point

108-110 oC

Acapodene H2O Solubility

No information avaliable

Acapodene State


Acapodene LogP


Acapodene Dosage Forms


Acapodene Indication

For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors

Acapodene Pharmacology

Toremifene is an antineoplastic hormonal agent primarily used in the treatment of advanced breast cancer. Toremifene is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Toremifene inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, Toremifene appears to exert its antitumor effects by binding the estrogen receptors. In cytosols derived from human breast adenocarcinomas, Toremifene competes with estradiol for estrogen receptor protein.

Acapodene Absorption

Well absorbed

Acapodene side effects and Toxicity

No information avaliable

Acapodene Patient Information

Patient Information:

Vaginal bleeding has been reported in patients using Toremifene. Patients should be informed about
this and instructed to contact their physician if such bleeding occurs.

Patients with bone metastases should be informed about the typical signs and symptoms of hypercalcemia
and instructed to contact their physician for further assessment if such signs or symptoms occur.

Acapodene Organisms Affected

Humans and other mammals