Apaetp en es it fr

Apaetp Brand names, Apaetp Analogs

Apaetp Brand Names Mixture

  • No information avaliable

Apaetp Chemical_Formula

C5H15N2O3PS

Apaetp RX_link

http://www.rxlist.com/cgi/generic/amifostine.htm

Apaetp fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=118

Apaetp msds (material safety sheet)

Apaetp MSDS

Apaetp Synthesis Reference

No information avaliable

Apaetp Molecular Weight

214.224 g/mol

Apaetp Melting Point

No information avaliable

Apaetp H2O Solubility

1000 mg/mL

Apaetp State

Solid

Apaetp LogP

-1.043

Apaetp Dosage Forms

Powder for solution

Apaetp Indication

For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.

Apaetp Pharmacology

Amifostine is an organic thiophosphate cytoprotective agent indicated to reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer or non-small cell lung cancer and also to reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer. Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite, believed to be responsible for the reduction of the cumulative renal toxicity of cisplatin and for the reduction of the toxic effects of radiation on normal oral tissues. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumour cells.

Apaetp Absorption

No information avaliable

Apaetp side effects and Toxicity

Rat LD50: 826 mg/kg

Apaetp Patient Information

No information avaliable

Apaetp Organisms Affected

Humans and other mammals