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SAPEP Brand names, SAPEP Analogs

SAPEP Brand Names Mixture

  • No information avaliable

SAPEP Chemical_Formula

C5H15N2O3PS

SAPEP RX_link

http://www.rxlist.com/cgi/generic/amifostine.htm

SAPEP fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=118

SAPEP msds (material safety sheet)

SAPEP MSDS

SAPEP Synthesis Reference

No information avaliable

SAPEP Molecular Weight

214.224 g/mol

SAPEP Melting Point

No information avaliable

SAPEP H2O Solubility

1000 mg/mL

SAPEP State

Solid

SAPEP LogP

-1.043

SAPEP Dosage Forms

Powder for solution

SAPEP Indication

For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.

SAPEP Pharmacology

Amifostine is an organic thiophosphate cytoprotective agent indicated to reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer or non-small cell lung cancer and also to reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer. Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite, believed to be responsible for the reduction of the cumulative renal toxicity of cisplatin and for the reduction of the toxic effects of radiation on normal oral tissues. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumour cells.

SAPEP Absorption

No information avaliable

SAPEP side effects and Toxicity

Rat LD50: 826 mg/kg

SAPEP Patient Information

No information avaliable

SAPEP Organisms Affected

Humans and other mammals