PharmacyCodes



Amifostine Ethiofos en es it fr

Amifostine Ethiofos Brand names, Amifostine Ethiofos Analogs

Amifostine Ethiofos Brand Names Mixture

  • No information avaliable

Amifostine Ethiofos Chemical_Formula

C5H15N2O3PS

Amifostine Ethiofos RX_link

http://www.rxlist.com/cgi/generic/amifostine.htm

Amifostine Ethiofos fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=118

Amifostine Ethiofos msds (material safety sheet)

Amifostine_Ethiofos MSDS

Amifostine Ethiofos Synthesis Reference

No information avaliable

Amifostine Ethiofos Molecular Weight

214.224 g/mol

Amifostine Ethiofos Melting Point

No information avaliable

Amifostine Ethiofos H2O Solubility

1000 mg/mL

Amifostine Ethiofos State

Solid

Amifostine Ethiofos LogP

-1.043

Amifostine Ethiofos Dosage Forms

Powder for solution

Amifostine Ethiofos Indication

For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.

Amifostine Ethiofos Pharmacology

Amifostine is an organic thiophosphate cytoprotective agent indicated to reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer or non-small cell lung cancer and also to reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer. Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite, believed to be responsible for the reduction of the cumulative renal toxicity of cisplatin and for the reduction of the toxic effects of radiation on normal oral tissues. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumour cells.

Amifostine Ethiofos Absorption

No information avaliable

Amifostine Ethiofos side effects and Toxicity

Rat LD50: 826 mg/kg

Amifostine Ethiofos Patient Information

No information avaliable

Amifostine Ethiofos Organisms Affected

Humans and other mammals