Aminopropylaminoethyl Thiophosphate
Aminopropylaminoethyl Thiophosphate Brand names, Aminopropylaminoethyl Thiophosphate Analogs
Aminopropylaminoethyl Thiophosphate Brand Names Mixture
- No information avaliable
Aminopropylaminoethyl Thiophosphate Chemical_Formula
C5H15N2O3PS
Aminopropylaminoethyl Thiophosphate RX_link
http://www.rxlist.com/cgi/generic/amifostine.htm
Aminopropylaminoethyl Thiophosphate fda sheet
Aminopropylaminoethyl Thiophosphate msds (material safety sheet)
Aminopropylaminoethyl Thiophosphate Synthesis Reference
No information avaliable
Aminopropylaminoethyl Thiophosphate Molecular Weight
214.224 g/mol
Aminopropylaminoethyl Thiophosphate Melting Point
No information avaliable
Aminopropylaminoethyl Thiophosphate H2O Solubility
1000 mg/mL
Aminopropylaminoethyl Thiophosphate State
Solid
Aminopropylaminoethyl Thiophosphate LogP
-1.043
Aminopropylaminoethyl Thiophosphate Dosage Forms
Powder for solution
Aminopropylaminoethyl Thiophosphate Indication
For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
Aminopropylaminoethyl Thiophosphate Pharmacology
Amifostine is an organic thiophosphate cytoprotective agent indicated to reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer or non-small cell lung cancer and also to reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer. Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite, believed to be responsible for the reduction of the cumulative renal toxicity of cisplatin and for the reduction of the toxic effects of radiation on normal oral tissues. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumour cells.
Aminopropylaminoethyl Thiophosphate Absorption
No information avaliable
Aminopropylaminoethyl Thiophosphate side effects and Toxicity
Rat LD50: 826 mg/kg
Aminopropylaminoethyl Thiophosphate Patient Information
No information avaliable
Aminopropylaminoethyl Thiophosphate Organisms Affected
Humans and other mammals
