Tacrine
Tacrine Brand names, Tacrine Analogs
Tacrine Brand Names Mixture
- No information avaliable
Tacrine Chemical_Formula
C13H14N2
Tacrine RX_link
http://www.rxlist.com/cgi/generic2/tacrine.htm
Tacrine fda sheet
Tacrine msds (material safety sheet)
Tacrine Synthesis Reference
No information avaliable
Tacrine Molecular Weight
198.264 g/mol
Tacrine Melting Point
183.5 oC
Tacrine H2O Solubility
217 mg/L
Tacrine State
Solid
Tacrine LogP
2.298
Tacrine Dosage Forms
No information avaliable
Tacrine Indication
For the treatment of mild to moderate dementia of the Alzheimer's type.
Tacrine Pharmacology
Tacrine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Tacrine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, tacrine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that tacrine alters the course of the underlying dementing process.
Tacrine Absorption
Tacrine is rapidly absorbed. Absolute bioavailability of tacrine is approximately 17 ± 13%.
Tacrine side effects and Toxicity
No information avaliable
Tacrine Patient Information
No information avaliable
Tacrine Organisms Affected
Humans and other mammals
