Tetrahydroaminoacridine
Tetrahydroaminoacridine Brand names, Tetrahydroaminoacridine Analogs
Tetrahydroaminoacridine Brand Names Mixture
- No information avaliable
Tetrahydroaminoacridine Chemical_Formula
C13H14N2
Tetrahydroaminoacridine RX_link
http://www.rxlist.com/cgi/generic2/tacrine.htm
Tetrahydroaminoacridine fda sheet
Tetrahydroaminoacridine msds (material safety sheet)
Tetrahydroaminoacridine Synthesis Reference
No information avaliable
Tetrahydroaminoacridine Molecular Weight
198.264 g/mol
Tetrahydroaminoacridine Melting Point
183.5 oC
Tetrahydroaminoacridine H2O Solubility
217 mg/L
Tetrahydroaminoacridine State
Solid
Tetrahydroaminoacridine LogP
2.298
Tetrahydroaminoacridine Dosage Forms
No information avaliable
Tetrahydroaminoacridine Indication
For the treatment of mild to moderate dementia of the Alzheimer's type.
Tetrahydroaminoacridine Pharmacology
Tacrine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Tacrine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, tacrine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that tacrine alters the course of the underlying dementing process.
Tetrahydroaminoacridine Absorption
Tacrine is rapidly absorbed. Absolute bioavailability of tacrine is approximately 17 ± 13%.
Tetrahydroaminoacridine side effects and Toxicity
No information avaliable
Tetrahydroaminoacridine Patient Information
No information avaliable
Tetrahydroaminoacridine Organisms Affected
Humans and other mammals
