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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C13H14N2
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RX_link
http://www.rxlist.com/cgi/generic2/tacrine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
198.264 g/mol
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Melting Point
183.5 oC
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H2O Solubility
217 mg/L
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State
Solid
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LogP
2.298
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Dosage Forms
No information avaliable
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Indication
For the treatment of mild to moderate dementia of the Alzheimer's type.
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Pharmacology
Tacrine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Tacrine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, tacrine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that tacrine alters the course of the underlying dementing process.
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Absorption
Tacrine is rapidly absorbed. Absolute bioavailability of tacrine is approximately 17 ± 13%.
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals