TAK

TAK Brand names, TAK Analogs

TAK Brand Names Mixture

No information avaliable

TAK Chemical_Formula

C₁₆H₁₄F₃N₃O₂S

TAK RX_link

http://www.rxlist.com/cgi/generic/lansop.htm

TAK fda sheet

TAK FDA

TAK msds (material safety sheet)

TAK Synthesis Reference

A. Nohara, Y. Marki, U.S. Pat. 4,628,098 (1986)

TAK Molecular Weight

369.363 g/mol

TAK Melting Point

178-182 ^oC

TAK H₂O Solubility

0.97 mg/L

TAK State

Solid

TAK LogP

1.733

TAK Dosage Forms

Enteric coated capsules

TAK Indication

For treatment of Acid-reflux disorders (GERD), peptic Ulcer Disease, duodenal ulcers, esophagitis, and Zollinger-Ellison syndrome

TAK Pharmacology

Lansoprazole, an acid proton-pump inhibitor similar to omeprazole, is used as an untiulcer drug in the treatment and maintenance of healing of duodenal or gastric ulcers, erosive and reflux esophagitis, NSAID-induced ulcer, Zollinger-Ellison syndrome, and Barrett's esophagus. Lansoprozole is active against Helicobacter pylori. The plasma elimination half-life of lansoprazole does not reflect its duration of suppression of gastric acid secretion. Thus, the plasma elimination half-life is less than two hours, while the acid inhibitory effect lasts more than 24 hours.

TAK Absorption

The absorption of lansoprazole is rapid, with mean C_max occurring approximately 1.7 hours after oral dosing, and relatively complete with absolute bioavailability over 80%.

TAK side effects and Toxicity

Symptoms of overdose include abdominal pain, nausea and diarrhea.

TAK Patient Information

Lansoprazole is used short-term (4-8 weeks) to treat duodenal ulcer and erosive esophagitis. It may used long term to treat Zollinger-Ellison syndrome, a problem with too much acid being secreted. Lansoprazole capsules should be taken before eating. The capsules are delayed release' meaning they work over time. The capsules should be swallowed whole and not crushed, opened or chewed. If you are taking theophylline, you may need your dosage checked when you start and stop lansoprazole to ensure your dose is effective. If you are taking sucralfate, it should be taken 30 minutes after taking lansoprazole. The most common side effects reported were diarrhea, nausea and abdominal pain. These occurred in fewer than 5% of patients. If your symptoms return after completing your course of therapy, talk to your physician for further evaluation.

TAK Organisms Affected

Humans and other mammals

TAK