Amarin

Amarin Brand names, Amarin Analogs

Amarin Brand Names Mixture

No information avaliable

Amarin Chemical_Formula

C₁₆H₁₄F₃N₃O₂S

Amarin RX_link

http://www.rxlist.com/cgi/generic/lansop.htm

Amarin fda sheet

Amarin FDA

Amarin msds (material safety sheet)

Amarin Synthesis Reference

A. Nohara, Y. Marki, U.S. Pat. 4,628,098 (1986)

Amarin Molecular Weight

369.363 g/mol

Amarin Melting Point

178-182 ^oC

Amarin H₂O Solubility

0.97 mg/L

Amarin State

Solid

Amarin LogP

1.733

Amarin Dosage Forms

Enteric coated capsules

Amarin Indication

For treatment of Acid-reflux disorders (GERD), peptic Ulcer Disease, duodenal ulcers, esophagitis, and Zollinger-Ellison syndrome

Amarin Pharmacology

Lansoprazole, an acid proton-pump inhibitor similar to omeprazole, is used as an untiulcer drug in the treatment and maintenance of healing of duodenal or gastric ulcers, erosive and reflux esophagitis, NSAID-induced ulcer, Zollinger-Ellison syndrome, and Barrett's esophagus. Lansoprozole is active against Helicobacter pylori. The plasma elimination half-life of lansoprazole does not reflect its duration of suppression of gastric acid secretion. Thus, the plasma elimination half-life is less than two hours, while the acid inhibitory effect lasts more than 24 hours.

Amarin Absorption

The absorption of lansoprazole is rapid, with mean C_max occurring approximately 1.7 hours after oral dosing, and relatively complete with absolute bioavailability over 80%.

Amarin side effects and Toxicity

Symptoms of overdose include abdominal pain, nausea and diarrhea.

Amarin Patient Information

Lansoprazole is used short-term (4-8 weeks) to treat duodenal ulcer and erosive esophagitis. It may used long term to treat Zollinger-Ellison syndrome, a problem with too much acid being secreted. Lansoprazole capsules should be taken before eating. The capsules are delayed release' meaning they work over time. The capsules should be swallowed whole and not crushed, opened or chewed. If you are taking theophylline, you may need your dosage checked when you start and stop lansoprazole to ensure your dose is effective. If you are taking sucralfate, it should be taken 30 minutes after taking lansoprazole. The most common side effects reported were diarrhea, nausea and abdominal pain. These occurred in fewer than 5% of patients. If your symptoms return after completing your course of therapy, talk to your physician for further evaluation.

Amarin Organisms Affected

Humans and other mammals