Lanz
Brand names,
Lanz
Analogs
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Brand Names Mixture
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Chemical_Formula
C16H14F3N3O2S
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RX_link
http://www.rxlist.com/cgi/generic/lansop.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
A. Nohara, Y. Marki, U.S. Pat. 4,628,098 (1986)
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Molecular Weight
369.363 g/mol
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Melting Point
178-182 oC
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H2O Solubility
0.97 mg/L
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State
Solid
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LogP
1.733
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Dosage Forms
Enteric coated capsules
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Indication
For treatment of Acid-reflux disorders (GERD), peptic Ulcer Disease, duodenal ulcers, esophagitis, and Zollinger-Ellison syndrome
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Pharmacology
Lansoprazole, an acid proton-pump inhibitor similar to omeprazole, is used as an untiulcer drug in the treatment and maintenance of healing of duodenal or gastric ulcers, erosive and reflux esophagitis, NSAID-induced ulcer, Zollinger-Ellison syndrome, and Barrett's esophagus. Lansoprozole is active against Helicobacter pylori. The plasma elimination half-life of lansoprazole does not reflect its duration of suppression of gastric acid secretion. Thus, the plasma elimination half-life is less than two hours, while the acid inhibitory effect lasts more than 24 hours.
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Absorption
The absorption of lansoprazole is rapid, with mean Cmax occurring approximately 1.7 hours after oral dosing, and relatively complete with absolute bioavailability over 80%.
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side effects and Toxicity
Symptoms of overdose include abdominal pain, nausea and diarrhea.
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Patient Information
Lansoprazole is used short-term (4-8 weeks) to treat duodenal ulcer and erosive esophagitis. It may used long term
to treat Zollinger-Ellison syndrome, a problem with too much acid being secreted. Lansoprazole capsules should be
taken before eating. The capsules are delayed release' meaning they work over time. The capsules should be swallowed
whole and not crushed, opened or chewed. If you are taking theophylline, you may need your dosage checked when you
start and stop lansoprazole to ensure your dose is effective. If you are taking sucralfate, it should be taken 30
minutes after taking lansoprazole. The most common side effects reported were diarrhea, nausea and abdominal pain.
These occurred in fewer than 5% of patients. If your symptoms return after completing your course of therapy, talk to
your physician for further evaluation.
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Organisms Affected
Humans and other mammals