Sporanox

• Antiprotozoals
• Antifungals
• ATC:J02AC02

• ITC
• ITCZ
• ITR
• ITZ
• Itraconazol [Spanish]
• Itraconazole & Bovine Lactoferrin
• Itraconazole [Usan:Ban:Inn:Jan]
• Itraconazolum [Latin]
• Itrizole
• Oriconazole
• Sporal
• Sporanos
• Sporanox
• Sporonox
• Triasporn

• No information avaliable

C₃₅H₃₈Cl₂N₈O₄

http://www.rxlist.com/cgi/generic/itraconazole.htm

Sporanox FDA

Sporanox MSDS

No information avaliable

705.633 g/mol

166.2 ^oC

Insoluble

Solid

6.939

Capsules (100 mg); Liquid solution

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itraconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.

The absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.

No significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.

No information avaliable

Fungi, yeast and protozoans