Itraconazole & Bovine Lactoferrin
Itraconazole & Bovine Lactoferrin Brand names, Itraconazole & Bovine Lactoferrin Analogs
Itraconazole & Bovine Lactoferrin Brand Names Mixture
- No information avaliable
Itraconazole & Bovine Lactoferrin Chemical_Formula
C35H38Cl2N8O4
Itraconazole & Bovine Lactoferrin RX_link
http://www.rxlist.com/cgi/generic/itraconazole.htm
Itraconazole & Bovine Lactoferrin fda sheet
Itraconazole & Bovine Lactoferrin msds (material safety sheet)
Itraconazole & Bovine Lactoferrin Synthesis Reference
No information avaliable
Itraconazole & Bovine Lactoferrin Molecular Weight
705.633 g/mol
Itraconazole & Bovine Lactoferrin Melting Point
166.2 oC
Itraconazole & Bovine Lactoferrin H2O Solubility
Insoluble
Itraconazole & Bovine Lactoferrin State
Solid
Itraconazole & Bovine Lactoferrin LogP
6.939
Itraconazole & Bovine Lactoferrin Dosage Forms
Capsules (100 mg); Liquid solution
Itraconazole & Bovine Lactoferrin Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Itraconazole & Bovine Lactoferrin Pharmacology
Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itraconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.
Itraconazole & Bovine Lactoferrin Absorption
The absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.
Itraconazole & Bovine Lactoferrin side effects and Toxicity
No significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.
Itraconazole & Bovine Lactoferrin Patient Information
No information avaliable
Itraconazole & Bovine Lactoferrin Organisms Affected
Fungi, yeast and protozoans
