Itrizole

Itrizole Brand names, Itrizole Analogs

Itrizole Brand Names Mixture

No information avaliable

Itrizole Chemical_Formula

C₃₅H₃₈Cl₂N₈O₄

Itrizole RX_link

http://www.rxlist.com/cgi/generic/itraconazole.htm

Itrizole fda sheet

Itrizole FDA

Itrizole msds (material safety sheet)

Itrizole MSDS

Itrizole Synthesis Reference

No information avaliable

Itrizole Molecular Weight

705.633 g/mol

Itrizole Melting Point

166.2 ^oC

Itrizole H₂O Solubility

Insoluble

Itrizole State

Solid

Itrizole LogP

6.939

Itrizole Dosage Forms

Capsules (100 mg); Liquid solution

Itrizole Indication

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

Itrizole Pharmacology

Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itraconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.

Itrizole Absorption

The absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.

Itrizole side effects and Toxicity

No significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.

Itrizole Patient Information