ITR

ITR Brand names, ITR Analogs

ITR Brand Names Mixture

No information avaliable

ITR Chemical_Formula

C₃₅H₃₈Cl₂N₈O₄

ITR RX_link

http://www.rxlist.com/cgi/generic/itraconazole.htm

ITR fda sheet

ITR FDA

ITR msds (material safety sheet)

ITR MSDS

ITR Synthesis Reference

No information avaliable

ITR Molecular Weight

705.633 g/mol

ITR Melting Point

166.2 ^oC

ITR H₂O Solubility

Insoluble

ITR State

Solid

ITR LogP

6.939

ITR Dosage Forms

Capsules (100 mg); Liquid solution

ITR Indication

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

ITR Pharmacology

Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itraconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.

ITR Absorption

The absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.

ITR side effects and Toxicity

No significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.

ITR Patient Information