Roxithromycin
Roxithromycin Brand names, Roxithromycin Analogs
Roxithromycin Brand Names Mixture
- No information avaliable
Roxithromycin Chemical_Formula
C41H76N2O15
Roxithromycin RX_link
No information avaliable
Roxithromycin fda sheet
Roxithromycin msds (material safety sheet)
Roxithromycin Synthesis Reference
No information avaliable
Roxithromycin Molecular Weight
837.047 g/mol
Roxithromycin Melting Point
No information avaliable
Roxithromycin H2O Solubility
0.0189 mg/L at 25 oC (SRC PhysProp estimated -- MEYLAN,WM et al. (1996))
Roxithromycin State
Solid
Roxithromycin LogP
2.292
Roxithromycin Dosage Forms
Tablets; Oral suspension
Roxithromycin Indication
Used to treat respiratory tract, urinary and soft tissue infections.
Roxithromycin Pharmacology
Roxithromycin is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithromycin has the following antibacterial spectrum in vitro: Streptococcus agalactiae, Streptococcus pneumoniae (Pneumococcus), Neisseria meningitides (Meningococcus), Listeria monocytogenes, Mycoplasma pneumoniae, Chlamydia trachomatis, Ureaplasma urealyticum, Legionella pneumophila, Helicobacter (Campylobacter), Gardnerella vaginalis, Bordetella pertussis, Moraxella catarrhalis (Branhamella Catarrhalis), and Haemophilus ducreyi. Roxithromycin is highly concentrated in polymorphonuclear leukocytes and macrophages, achieving intracellular concentrations greater than those outside the cell. Roxithromycin enhances the adhesive and chemotactic functions of these cells which in the presence of infection produce phagocytosis and bacterial lysis. Roxithromycin also possesses intracellular bactericidal activity.
Roxithromycin Absorption
Very rapidly absorbed and diffused into most tissues and phagocytes.
Roxithromycin side effects and Toxicity
Most common side-effects are gastrointestinal; diarrhoea, nausea, abdominal pain and vomiting. Less common side-effects include headaches, rashes, abnormal liver function values and alteration in senses of smell and taste.
Roxithromycin Patient Information
Roxithromycin Organisms Affected
Enteric bacteria and other eubacteria
