(-)-Ranolazine
Brand names,
(-)-Ranolazine
Analogs
(-)-Ranolazine
Brand Names Mixture
(-)-Ranolazine
Chemical_Formula
C41H76N2O15
(-)-Ranolazine
RX_link
No information avaliable
(-)-Ranolazine
fda sheet
(-)-Ranolazine
msds (material safety sheet)
(-)-Ranolazine
Synthesis Reference
No information avaliable
(-)-Ranolazine
Molecular Weight
837.047 g/mol
(-)-Ranolazine
Melting Point
No information avaliable
(-)-Ranolazine
H2O Solubility
0.0189 mg/L at 25 oC (SRC PhysProp estimated -- MEYLAN,WM et al. (1996))
(-)-Ranolazine
State
Solid
(-)-Ranolazine
LogP
2.292
(-)-Ranolazine
Dosage Forms
Tablets; Oral suspension
(-)-Ranolazine
Indication
Used to treat respiratory tract, urinary and soft tissue infections.
(-)-Ranolazine
Pharmacology
Roxithromycin is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithromycin has the following antibacterial spectrum in vitro: Streptococcus agalactiae, Streptococcus pneumoniae (Pneumococcus), Neisseria meningitides (Meningococcus), Listeria monocytogenes, Mycoplasma pneumoniae, Chlamydia trachomatis, Ureaplasma urealyticum, Legionella pneumophila, Helicobacter (Campylobacter), Gardnerella vaginalis, Bordetella pertussis, Moraxella catarrhalis (Branhamella Catarrhalis), and Haemophilus ducreyi. Roxithromycin is highly concentrated in polymorphonuclear leukocytes and macrophages, achieving intracellular concentrations greater than those outside the cell. Roxithromycin enhances the adhesive and chemotactic functions of these cells which in the presence of infection produce phagocytosis and bacterial lysis. Roxithromycin also possesses intracellular bactericidal activity.
(-)-Ranolazine
Absorption
Very rapidly absorbed and diffused into most tissues and phagocytes.
(-)-Ranolazine
side effects and Toxicity
Most common side-effects are gastrointestinal; diarrhoea, nausea, abdominal pain and vomiting. Less common side-effects include headaches, rashes, abnormal liver function values and alteration in senses of smell and taste.
(-)-Ranolazine
Patient Information
(-)-Ranolazine
Organisms Affected
Enteric bacteria and other eubacteria