Ropinirole

Ropinirole Brand names, Ropinirole Analogs

Ropinirole Brand Names Mixture

No information avaliable

Ropinirole Chemical_Formula

C₁₆H₂₄N₂O

Ropinirole RX_link

http://www.rxlist.com/cgi/generic2/ropinirole.htm

Ropinirole fda sheet

Ropinirole FDA

Ropinirole msds (material safety sheet)

Ropinirole MSDS

Ropinirole Synthesis Reference

No information avaliable

Ropinirole Molecular Weight

260.375 g/mol

Ropinirole Melting Point

243-250 ^oC

Ropinirole H₂O Solubility

133 mg/mL

Ropinirole State

Solid

Ropinirole LogP

2.72

Ropinirole Dosage Forms

Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

Ropinirole Indication

For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

Ropinirole Pharmacology

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D₂ subfamily of dopamine receptors, binding with higher affinity to D₃ than to D₂ or D₄ receptor subtypes. The relevance of D₃ receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D₂ -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

Ropinirole Absorption

Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

Ropinirole side effects and Toxicity

Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

Ropinirole Patient Information