Ropinirol [INN-Spanish]

Ropinirol [INN-Spanish] Brand names, Ropinirol [INN-Spanish] Analogs

Ropinirol [INN-Spanish] Brand Names Mixture

No information avaliable

Ropinirol [INN-Spanish] Chemical_Formula

C₁₆H₂₄N₂O

Ropinirol [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic2/ropinirole.htm

Ropinirol [INN-Spanish] fda sheet

Ropinirol_[INN-Spanish] FDA

Ropinirol [INN-Spanish] msds (material safety sheet)

Ropinirol_[INN-Spanish] MSDS

Ropinirol [INN-Spanish] Synthesis Reference

No information avaliable

Ropinirol [INN-Spanish] Molecular Weight

260.375 g/mol

Ropinirol [INN-Spanish] Melting Point

243-250 ^oC

Ropinirol [INN-Spanish] H₂O Solubility

133 mg/mL

Ropinirol [INN-Spanish] State

Solid

Ropinirol [INN-Spanish] LogP

2.72

Ropinirol [INN-Spanish] Dosage Forms

Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

Ropinirol [INN-Spanish] Indication

For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

Ropinirol [INN-Spanish] Pharmacology

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D₂ subfamily of dopamine receptors, binding with higher affinity to D₃ than to D₂ or D₄ receptor subtypes. The relevance of D₃ receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D₂ -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

Ropinirol [INN-Spanish] Absorption

Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

Ropinirol [INN-Spanish] side effects and Toxicity

Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

Ropinirol [INN-Spanish] Patient Information