Ropinirole HCl

Ropinirole HCl Brand names, Ropinirole HCl Analogs

Ropinirole HCl Brand Names Mixture

No information avaliable

Ropinirole HCl Chemical_Formula

C₁₆H₂₄N₂O

Ropinirole HCl RX_link

http://www.rxlist.com/cgi/generic2/ropinirole.htm

Ropinirole HCl fda sheet

Ropinirole_HCl FDA

Ropinirole HCl msds (material safety sheet)

Ropinirole_HCl MSDS

Ropinirole HCl Synthesis Reference

No information avaliable

Ropinirole HCl Molecular Weight

260.375 g/mol

Ropinirole HCl Melting Point

243-250 ^oC

Ropinirole HCl H₂O Solubility

133 mg/mL

Ropinirole HCl State

Solid

Ropinirole HCl LogP

2.72

Ropinirole HCl Dosage Forms

Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

Ropinirole HCl Indication

For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

Ropinirole HCl Pharmacology

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D₂ subfamily of dopamine receptors, binding with higher affinity to D₃ than to D₂ or D₄ receptor subtypes. The relevance of D₃ receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D₂ -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

Ropinirole HCl Absorption

Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

Ropinirole HCl side effects and Toxicity

Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

Ropinirole HCl Patient Information