Ropinirole hydrochloride

Ropinirole hydrochloride Brand names, Ropinirole hydrochloride Analogs

Ropinirole hydrochloride Brand Names Mixture

No information avaliable

Ropinirole hydrochloride Chemical_Formula

C₁₆H₂₄N₂O

Ropinirole hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/ropinirole.htm

Ropinirole hydrochloride fda sheet

Ropinirole_hydrochloride FDA

Ropinirole hydrochloride msds (material safety sheet)

Ropinirole_hydrochloride MSDS

Ropinirole hydrochloride Synthesis Reference

No information avaliable

Ropinirole hydrochloride Molecular Weight

260.375 g/mol

Ropinirole hydrochloride Melting Point

243-250 ^oC

Ropinirole hydrochloride H₂O Solubility

133 mg/mL

Ropinirole hydrochloride State

Solid

Ropinirole hydrochloride LogP

2.72

Ropinirole hydrochloride Dosage Forms

Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

Ropinirole hydrochloride Indication

For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

Ropinirole hydrochloride Pharmacology

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D₂ subfamily of dopamine receptors, binding with higher affinity to D₃ than to D₂ or D₄ receptor subtypes. The relevance of D₃ receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D₂ -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

Ropinirole hydrochloride Absorption

Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

Ropinirole hydrochloride side effects and Toxicity

Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

Ropinirole hydrochloride Patient Information