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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C18H22N2
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
266.381 g/mol
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Melting Point
No information avaliable
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H2O Solubility
No information avaliable
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State
Solid
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LogP
3.338
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Dosage Forms
Liquid
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Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems).
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Pharmacology
Cyclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Cyclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which cyclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
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Absorption
No information avaliable
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals