Propafenonum [INN-Latin] en es it fr

Propafenonum [INN-Latin] Brand names, Propafenonum [INN-Latin] Analogs

Propafenonum [INN-Latin] Brand Names Mixture

  • No information avaliable

Propafenonum [INN-Latin] Chemical_Formula


Propafenonum [INN-Latin] RX_link

Propafenonum [INN-Latin] fda sheet

Propafenonum_[INN-Latin] FDA

Propafenonum [INN-Latin] msds (material safety sheet)

Propafenonum_[INN-Latin] MSDS

Propafenonum [INN-Latin] Synthesis Reference

No information avaliable

Propafenonum [INN-Latin] Molecular Weight

341.444 g/mol

Propafenonum [INN-Latin] Melting Point

No information avaliable

Propafenonum [INN-Latin] H2O Solubility

Slightly soluble

Propafenonum [INN-Latin] State


Propafenonum [INN-Latin] LogP


Propafenonum [INN-Latin] Dosage Forms

Tablet (150, 225 and 300 mg)

Propafenonum [INN-Latin] Indication

Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.

Propafenonum [INN-Latin] Pharmacology

Propafenone is a Class 1C antiarrhythmic drug with local anesthetic effects, and a direct stabilizing action on myocardial membranes. It is used in the treatment of atrial and ventricular arrhythmias. It works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitablity of the cells. Propafenone has local anesthetic activity approximately equal to procaine.

Propafenonum [INN-Latin] Absorption

Nearly completely absorbed following oral administration (90%). Systemic bioavailability ranges from 5 to 50%, due to significant first-pass metabolism. This wide range in systemic bioavailability is related to two factors: presence of food (food increases bioavailability) and dosage (bioavailability is 3.4% for a 150-mg tablet compared to 10.6% for a 300-mg tablet).

Propafenonum [INN-Latin] side effects and Toxicity

Symptoms of propafenone overdose (usually most severe within the first 3 hours) may include convulsions (rarely), heartbeat irregularities, low blood pressure, and sleepiness.

Propafenonum [INN-Latin] Patient Information

No information avaliable

Propafenonum [INN-Latin] Organisms Affected

Humans and other mammals