PharmacyCodes



Propafenona [INN-Spanish] en es it fr

Propafenona [INN-Spanish] Brand names, Propafenona [INN-Spanish] Analogs

Propafenona [INN-Spanish] Brand Names Mixture

  • No information avaliable

Propafenona [INN-Spanish] Chemical_Formula

C21H27NO3

Propafenona [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic3/propafen.htm

Propafenona [INN-Spanish] fda sheet

Propafenona_[INN-Spanish] FDA

Propafenona [INN-Spanish] msds (material safety sheet)

Propafenona_[INN-Spanish] MSDS

Propafenona [INN-Spanish] Synthesis Reference

No information avaliable

Propafenona [INN-Spanish] Molecular Weight

341.444 g/mol

Propafenona [INN-Spanish] Melting Point

No information avaliable

Propafenona [INN-Spanish] H2O Solubility

Slightly soluble

Propafenona [INN-Spanish] State

Solid

Propafenona [INN-Spanish] LogP

3.34

Propafenona [INN-Spanish] Dosage Forms

Tablet (150, 225 and 300 mg)

Propafenona [INN-Spanish] Indication

Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.

Propafenona [INN-Spanish] Pharmacology

Propafenone is a Class 1C antiarrhythmic drug with local anesthetic effects, and a direct stabilizing action on myocardial membranes. It is used in the treatment of atrial and ventricular arrhythmias. It works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitablity of the cells. Propafenone has local anesthetic activity approximately equal to procaine.

Propafenona [INN-Spanish] Absorption

Nearly completely absorbed following oral administration (90%). Systemic bioavailability ranges from 5 to 50%, due to significant first-pass metabolism. This wide range in systemic bioavailability is related to two factors: presence of food (food increases bioavailability) and dosage (bioavailability is 3.4% for a 150-mg tablet compared to 10.6% for a 300-mg tablet).

Propafenona [INN-Spanish] side effects and Toxicity

Symptoms of propafenone overdose (usually most severe within the first 3 hours) may include convulsions (rarely), heartbeat irregularities, low blood pressure, and sleepiness.

Propafenona [INN-Spanish] Patient Information

No information avaliable

Propafenona [INN-Spanish] Organisms Affected

Humans and other mammals