PharmacyCodes



Propafenone-HCl en es it fr

Propafenone-HCl Brand names, Propafenone-HCl Analogs

Propafenone-HCl Brand Names Mixture

  • No information avaliable

Propafenone-HCl Chemical_Formula

C21H27NO3

Propafenone-HCl RX_link

http://www.rxlist.com/cgi/generic3/propafen.htm

Propafenone-HCl fda sheet

Propafenone-HCl FDA

Propafenone-HCl msds (material safety sheet)

Propafenone-HCl MSDS

Propafenone-HCl Synthesis Reference

No information avaliable

Propafenone-HCl Molecular Weight

341.444 g/mol

Propafenone-HCl Melting Point

No information avaliable

Propafenone-HCl H2O Solubility

Slightly soluble

Propafenone-HCl State

Solid

Propafenone-HCl LogP

3.34

Propafenone-HCl Dosage Forms

Tablet (150, 225 and 300 mg)

Propafenone-HCl Indication

Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.

Propafenone-HCl Pharmacology

Propafenone is a Class 1C antiarrhythmic drug with local anesthetic effects, and a direct stabilizing action on myocardial membranes. It is used in the treatment of atrial and ventricular arrhythmias. It works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitablity of the cells. Propafenone has local anesthetic activity approximately equal to procaine.

Propafenone-HCl Absorption

Nearly completely absorbed following oral administration (90%). Systemic bioavailability ranges from 5 to 50%, due to significant first-pass metabolism. This wide range in systemic bioavailability is related to two factors: presence of food (food increases bioavailability) and dosage (bioavailability is 3.4% for a 150-mg tablet compared to 10.6% for a 300-mg tablet).

Propafenone-HCl side effects and Toxicity

Symptoms of propafenone overdose (usually most severe within the first 3 hours) may include convulsions (rarely), heartbeat irregularities, low blood pressure, and sleepiness.

Propafenone-HCl Patient Information

No information avaliable

Propafenone-HCl Organisms Affected

Humans and other mammals