Placidyl
Placidyl Brand names, Placidyl Analogs
Placidyl Brand Names Mixture
- No information avaliable
Placidyl Chemical_Formula
C2H8O7P2
Placidyl RX_link
http://www.rxlist.com/cgi/generic2/didronel.htm
Placidyl fda sheet
Placidyl msds (material safety sheet)
Placidyl Synthesis Reference
No information avaliable
Placidyl Molecular Weight
206.028 g/mol
Placidyl Melting Point
No information avaliable
Placidyl H2O Solubility
No information avaliable
Placidyl State
Solid
Placidyl LogP
-2.734
Placidyl Dosage Forms
Solution for injection (50mg/mL); Tablet (200, 400 mg)
Placidyl Indication
For the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.
Placidyl Pharmacology
Etidronate is a first generation (non-nitrogenous) bisphosphonate in the same family as clodronate and tiludronate. Etidronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the etidronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Etidronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
Placidyl Absorption
The amount of drug absorbed after an oral dose is approximately 3%.
Placidyl side effects and Toxicity
Clinical experience with acute etidronate overdosage is extremely limited. Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients. Some patients may develop vomiting. In one event, an 18-year-old female who ingested an estimated single dose of 4800 to 6000 mg (67 to 100 mg/kg) of etidronate was reported to be mildly hypocalcemic (7 .5 2 mg/ dl) and experienced paresthesia of the fingers.
Placidyl Patient Information
Placidyl Organisms Affected
Humans and other mammals
