Pioglitazone
Pioglitazone Brand names, Pioglitazone Analogs
Pioglitazone Brand Names Mixture
- No information avaliable
Pioglitazone Chemical_Formula
C19H20N2O3S
Pioglitazone RX_link
http://www.rxlist.com/cgi/generic2/pioglit.htm
Pioglitazone fda sheet
Pioglitazone msds (material safety sheet)
Pioglitazone Synthesis Reference
K. Meguro, T. Fujita, U.S. Pat. 4,687,777 (1987)
Pioglitazone Molecular Weight
356.44 g/mol
Pioglitazone Melting Point
183-184oC
Pioglitazone H2O Solubility
mg/mL
Pioglitazone State
Solid
Pioglitazone LogP
No information avaliable
Pioglitazone Dosage Forms
Oral tablets
Pioglitazone Indication
Treatment of Type II diabetes mellitus
Pioglitazone Pharmacology
Pioglitazone, a member of the drug group known as the thiazolidinediones or "insulin sensitizers", is not chemically or functionally related to the alpha-glucosidase inhibitors, the biguanides, or the sulfonylureas. Pioglitazone targets insulin resistance and, hence, is used alone or in combination with insulin, metformin, or asulfonylurea as an antidiabetic agent.
Pioglitazone Absorption
Following oral administration, in the fasting state, pioglitazone is first measurable in serum within 30 minutes, with peak concentrations observed within 2 hours. Food slightly delays the time to peak serum concentration to 3 to 4 hours, but does not alter the extent of absorption.
Pioglitazone side effects and Toxicity
Hypogycemia; LD50=mg/kg (orally in rat)
Pioglitazone Patient Information
Pioglitazone Organisms Affected
Humans and other mammals
