Actost
Actost Brand names, Actost Analogs
Actost Brand Names Mixture
- No information avaliable
Actost Chemical_Formula
C19H20N2O3S
Actost RX_link
http://www.rxlist.com/cgi/generic2/pioglit.htm
Actost fda sheet
Actost msds (material safety sheet)
Actost Synthesis Reference
K. Meguro, T. Fujita, U.S. Pat. 4,687,777 (1987)
Actost Molecular Weight
356.44 g/mol
Actost Melting Point
183-184oC
Actost H2O Solubility
mg/mL
Actost State
Solid
Actost LogP
No information avaliable
Actost Dosage Forms
Oral tablets
Actost Indication
Treatment of Type II diabetes mellitus
Actost Pharmacology
Pioglitazone, a member of the drug group known as the thiazolidinediones or "insulin sensitizers", is not chemically or functionally related to the alpha-glucosidase inhibitors, the biguanides, or the sulfonylureas. Pioglitazone targets insulin resistance and, hence, is used alone or in combination with insulin, metformin, or asulfonylurea as an antidiabetic agent.
Actost Absorption
Following oral administration, in the fasting state, pioglitazone is first measurable in serum within 30 minutes, with peak concentrations observed within 2 hours. Food slightly delays the time to peak serum concentration to 3 to 4 hours, but does not alter the extent of absorption.
Actost side effects and Toxicity
Hypogycemia; LD50=mg/kg (orally in rat)
Actost Patient Information
Actost Organisms Affected
Humans and other mammals
