PharmacyCodes



Pilopine HS en es it fr

Pilopine HS Brand names, Pilopine HS Analogs

Pilopine HS Brand Names Mixture

  • E-Pilo 1 Ophthalmic Solution (Epinephrine bitartrate + Pilocarpine hydrochloride)
  • E-Pilo 2 Ophthalmic Solution (Epinephrine bitartrate + Pilocarpine hydrochloride)
  • E-Pilo 4 Ophthalmic Solution (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
  • E-Pilo 6 Ophthalmic Solution (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
  • E-Pilo-1 Oph Soln (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
  • E-Pilo-2 Oph Soln (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
  • E-Pilo-4 Oph Soln (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
  • E-Pilo-6 Oph Soln (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
  • Timpilo 2 (Pilocarpine Hydrochloride + Timolol Maleate)
  • Timpilo 4 (Pilocarpine Hydrochloride + Timolol Maleate)

Pilopine HS Chemical_Formula

C11H16N2O2

Pilopine HS RX_link

http://www.rxlist.com/cgi/generic3/salagen.htm

Pilopine HS fda sheet

Pilopine_HS FDA

Pilopine HS msds (material safety sheet)

Pilopine_HS MSDS

Pilopine HS Synthesis Reference

Preobrashenski et al., Ber. 66, 1187 (1933)

Pilopine HS Molecular Weight

208.257 g/mol

Pilopine HS Melting Point

34 oC

Pilopine HS H2O Solubility

1000 mg/ml

Pilopine HS State

Solid

Pilopine HS LogP

1.02

Pilopine HS Dosage Forms

Drops; Gel; Implant; Liquid; Solution

Pilopine HS Indication

For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.

Pilopine HS Pharmacology

Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. When applied topically to the eye as a single dose it causes miosis, spasm of accommodation, and may cause a transitory rise in intraocular pressure followed by a more persistent fall. Dose-related smooth muscle stimulation of the intestinal tract may cause increased tone, increased motility, spasm, and tenesmus. Bronchial smooth muscle tone may increase. The tone and motility of urinary tract, gallbladder, and biliary duct smooth muscle may be enhanced. Pilocarpine may have paradoxical effects on the cardiovascular system. The expected effect of a muscarinic agonist is vasodepression, but administration of pilocarpine may produce hypertension after a brief episode of hypotension. Bradycardia and tachycardia have both been reported with use of pilocarpine.

Pilopine HS Absorption

There was a decrease in the rate of absorption of pilocarpine from SALAGEN Tablets when taken with a high fat meal by 12 healthy male volunteers

Pilopine HS side effects and Toxicity

No information avaliable

Pilopine HS Patient Information

Patients should be informed that pilocarpine may cause visual disturbances, especially at night, that could impair their ability to drive safely.

If a patient sweats excessively while taking pilocarpine hydrochloride and cannot drink enough liquid, the patient should consult a physician. Dehydration may develop.

Pilopine HS Organisms Affected

Humans and other mammals