Pilocarpin
Pilocarpin Brand names, Pilocarpin Analogs
- Adsorbocarpine
- Akarpine
- Almocarpine
- Ami-Pilo
- Amistura P
- Beta-pilocarpine hydrochloride
- Epicar
- Isopto Carpine
- Isoptocarpine
- Mi-Pilo
- Mi-Pilo Ophth Sol
- Minims Pilocarpine
- Miocarpine
- Mistura P
- Ocu-Carpine
- Ocusert P 20
- Ocusert Pilo
- Ocusert Pilo-20
- Ocusert Pilo-40
- P.V. Carpine Liquifilm
- Pilagan
- Pilocar
- Pilocar SMP
- Pilocarpal
- Pilocarpin
- Pilocarpine chloride
- Pilocarpine HCl
- Pilocarpine hydrochloride
- Pilocarpine monohydrochloride
- Pilocarpine muriate
- Pilocarpine [Usan:Ban:Jan]
- Pilocarpol
- Pilocel
- Pilokarpin
- Pilokarpin monohydrochloride
- Pilokarpol
- Pilomiotin
- Pilopine HS
- Piloptic-1
- Piloptic-1/2
- Piloptic-2
- Piloptic-3
- Piloptic-4
- Piloptic-6
- Pilostat
- Pilovisc
- Salagen
- Sno Pilo
- Spersacarpine
- Spersacarpine hydrochloride
- Syncarpine
Pilocarpin Brand Names Mixture
- E-Pilo 1 Ophthalmic Solution (Epinephrine bitartrate + Pilocarpine hydrochloride)
- E-Pilo 2 Ophthalmic Solution (Epinephrine bitartrate + Pilocarpine hydrochloride)
- E-Pilo 4 Ophthalmic Solution (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
- E-Pilo 6 Ophthalmic Solution (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
- E-Pilo-1 Oph Soln (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
- E-Pilo-2 Oph Soln (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
- E-Pilo-4 Oph Soln (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
- E-Pilo-6 Oph Soln (Epinephrine Bitartrate + Pilocarpine Hydrochloride)
- Timpilo 2 (Pilocarpine Hydrochloride + Timolol Maleate)
- Timpilo 4 (Pilocarpine Hydrochloride + Timolol Maleate)
Pilocarpin Chemical_Formula
C11H16N2O2
Pilocarpin RX_link
http://www.rxlist.com/cgi/generic3/salagen.htm
Pilocarpin fda sheet
Pilocarpin msds (material safety sheet)
Pilocarpin Synthesis Reference
Preobrashenski et al., Ber. 66, 1187 (1933)
Pilocarpin Molecular Weight
208.257 g/mol
Pilocarpin Melting Point
34 oC
Pilocarpin H2O Solubility
1000 mg/ml
Pilocarpin State
Solid
Pilocarpin LogP
1.02
Pilocarpin Dosage Forms
Drops; Gel; Implant; Liquid; Solution
Pilocarpin Indication
For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
Pilocarpin Pharmacology
Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. When applied topically to the eye as a single dose it causes miosis, spasm of accommodation, and may cause a transitory rise in intraocular pressure followed by a more persistent fall. Dose-related smooth muscle stimulation of the intestinal tract may cause increased tone, increased motility, spasm, and tenesmus. Bronchial smooth muscle tone may increase. The tone and motility of urinary tract, gallbladder, and biliary duct smooth muscle may be enhanced. Pilocarpine may have paradoxical effects on the cardiovascular system. The expected effect of a muscarinic agonist is vasodepression, but administration of pilocarpine may produce hypertension after a brief episode of hypotension. Bradycardia and tachycardia have both been reported with use of pilocarpine.
Pilocarpin Absorption
There was a decrease in the rate of absorption of pilocarpine from SALAGEN Tablets when taken with a high fat meal by 12 healthy male volunteers
Pilocarpin side effects and Toxicity
No information avaliable
Pilocarpin Patient Information
Patients should be informed that pilocarpine may cause visual disturbances, especially at night, that could impair their ability to drive safely.
If a patient sweats excessively while taking pilocarpine hydrochloride and cannot drink enough liquid, the patient should consult a physician. Dehydration may develop.
Pilocarpin Organisms Affected
Humans and other mammals
