Ogostal
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C25H46N14O12S
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
766.786 g/mol
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Melting Point
No information avaliable
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H2O Solubility
Soluble in water as disulfate salt.
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State
Solid
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LogP
-9.609
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Dosage Forms
Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)
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Indication
Used in the treatment of tuberculosis in combination with other drugs.
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Pharmacology
Capreomycin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria, including bacteria responsible for causing tuberculosis (TB).
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Absorption
Not absorbed in significant quantities from the gastrointestinal tract and must be administered parenterally.
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side effects and Toxicity
Hypokalemia, hypocalcemia, hypomagnesemia, and an electrolyte disturbance resembling Bartter's syndrome have been reported to occur in patients with capreomycin toxicity. The subcutaneous median lethal dose (LD50) in mice was 514 mg/kg.
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Patient Information
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Organisms Affected
Enteric bacteria and other eubacteria