Mitotan

Mitotan Brand names, Mitotan Analogs

Mitotan Brand Names Mixture

No information avaliable

Mitotan Chemical_Formula

C₁₄H₁₀Cl₄

Mitotan RX_link

http://www.rxlist.com/cgi/generic2/mitotane.htm

Mitotan fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=mitotane

Mitotan msds (material safety sheet)

Mitotan MSDS

Mitotan Synthesis Reference

No information avaliable

Mitotan Molecular Weight

320.04 g/mol

Mitotan Melting Point

77 ^oC

Mitotan H₂O Solubility

0.1 mg/L

Mitotan State

Solid

Mitotan LogP

6.372

Mitotan Dosage Forms

Tablet

Mitotan Indication

For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Mitotan Pharmacology

Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Mitotan Absorption

About 40% oral Lysodren is absorbed

Mitotan side effects and Toxicity