Chlodithan

Chlodithan Brand names, Chlodithan Analogs

Chlodithan Brand Names Mixture

No information avaliable

Chlodithan Chemical_Formula

C₁₄H₁₀Cl₄

Chlodithan RX_link

http://www.rxlist.com/cgi/generic2/mitotane.htm

Chlodithan fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=mitotane

Chlodithan msds (material safety sheet)

Chlodithan MSDS

Chlodithan Synthesis Reference

No information avaliable

Chlodithan Molecular Weight

320.04 g/mol

Chlodithan Melting Point

77 ^oC

Chlodithan H₂O Solubility

0.1 mg/L

Chlodithan State

Solid

Chlodithan LogP

6.372

Chlodithan Dosage Forms

Tablet

Chlodithan Indication

For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Chlodithan Pharmacology

Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Chlodithan Absorption

About 40% oral Lysodren is absorbed

Chlodithan side effects and Toxicity