Chlodithane

Chlodithane Brand names, Chlodithane Analogs

Chlodithane Brand Names Mixture

No information avaliable

Chlodithane Chemical_Formula

C₁₄H₁₀Cl₄

Chlodithane RX_link

http://www.rxlist.com/cgi/generic2/mitotane.htm

Chlodithane fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=mitotane

Chlodithane msds (material safety sheet)

Chlodithane MSDS

Chlodithane Synthesis Reference

No information avaliable

Chlodithane Molecular Weight

320.04 g/mol

Chlodithane Melting Point

77 ^oC

Chlodithane H₂O Solubility

0.1 mg/L

Chlodithane State

Solid

Chlodithane LogP

6.372

Chlodithane Dosage Forms

Tablet

Chlodithane Indication

For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Chlodithane Pharmacology

Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Chlodithane Absorption

About 40% oral Lysodren is absorbed

Chlodithane side effects and Toxicity