Khlodithan

Khlodithan Brand names, Khlodithan Analogs

Khlodithan Brand Names Mixture

No information avaliable

Khlodithan Chemical_Formula

C₁₄H₁₀Cl₄

Khlodithan RX_link

http://www.rxlist.com/cgi/generic2/mitotane.htm

Khlodithan fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=mitotane

Khlodithan msds (material safety sheet)

Khlodithan MSDS

Khlodithan Synthesis Reference

No information avaliable

Khlodithan Molecular Weight

320.04 g/mol

Khlodithan Melting Point

77 ^oC

Khlodithan H₂O Solubility

0.1 mg/L

Khlodithan State

Solid

Khlodithan LogP

6.372

Khlodithan Dosage Forms

Tablet

Khlodithan Indication

For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Khlodithan Pharmacology

Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Khlodithan Absorption

About 40% oral Lysodren is absorbed

Khlodithan side effects and Toxicity