Lysodren

Lysodren Brand names, Lysodren Analogs

Lysodren Brand Names Mixture

No information avaliable

Lysodren Chemical_Formula

C₁₄H₁₀Cl₄

Lysodren RX_link

http://www.rxlist.com/cgi/generic2/mitotane.htm

Lysodren fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=mitotane

Lysodren msds (material safety sheet)

Lysodren MSDS

Lysodren Synthesis Reference

No information avaliable

Lysodren Molecular Weight

320.04 g/mol

Lysodren Melting Point

77 ^oC

Lysodren H₂O Solubility

0.1 mg/L

Lysodren State

Solid

Lysodren LogP

6.372

Lysodren Dosage Forms

Tablet

Lysodren Indication

For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Lysodren Pharmacology

Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Lysodren Absorption

About 40% oral Lysodren is absorbed

Lysodren side effects and Toxicity