Mexiletine

Mexiletine Brand names, Mexiletine Analogs

Mexiletine Brand Names Mixture

No information avaliable

Mexiletine Chemical_Formula

C₁₁H₁₇NO

Mexiletine RX_link

http://www.rxlist.com/cgi/generic3/mexiletine.htm

Mexiletine fda sheet

Mexiletine FDA

Mexiletine msds (material safety sheet)

Mexiletine MSDS

Mexiletine Synthesis Reference

No information avaliable

Mexiletine Molecular Weight

179.259 g/mol

Mexiletine Melting Point

203-205 ^oC

Mexiletine H₂O Solubility

8.25 mg/mL

Mexiletine State

Solid

Mexiletine LogP

2.039

Mexiletine Dosage Forms

Capsule (150 mg, 200 mg and 250 mg)

Mexiletine Indication

For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.

Mexiletine Pharmacology

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine has fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.

Mexiletine Absorption

Well absorbed (bioavailability 90%) from the gastrointenstinal tract.

Mexiletine side effects and Toxicity

Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.

Mexiletine Patient Information