Mexilitine

Mexilitine Brand names, Mexilitine Analogs

Mexilitine Brand Names Mixture

No information avaliable

Mexilitine Chemical_Formula

C₁₁H₁₇NO

Mexilitine RX_link

http://www.rxlist.com/cgi/generic3/mexiletine.htm

Mexilitine fda sheet

Mexilitine FDA

Mexilitine msds (material safety sheet)

Mexilitine MSDS

Mexilitine Synthesis Reference

No information avaliable

Mexilitine Molecular Weight

179.259 g/mol

Mexilitine Melting Point

203-205 ^oC

Mexilitine H₂O Solubility

8.25 mg/mL

Mexilitine State

Solid

Mexilitine LogP

2.039

Mexilitine Dosage Forms

Capsule (150 mg, 200 mg and 250 mg)

Mexilitine Indication

For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.

Mexilitine Pharmacology

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine has fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.

Mexilitine Absorption

Well absorbed (bioavailability 90%) from the gastrointenstinal tract.

Mexilitine side effects and Toxicity

Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.

Mexilitine Patient Information