Mexiletinum [INN-Latin]

Mexiletinum [INN-Latin] Brand names, Mexiletinum [INN-Latin] Analogs

Mexiletinum [INN-Latin] Brand Names Mixture

No information avaliable

Mexiletinum [INN-Latin] Chemical_Formula

C₁₁H₁₇NO

Mexiletinum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic3/mexiletine.htm

Mexiletinum [INN-Latin] fda sheet

Mexiletinum_[INN-Latin] FDA

Mexiletinum [INN-Latin] msds (material safety sheet)

Mexiletinum_[INN-Latin] MSDS

Mexiletinum [INN-Latin] Synthesis Reference

No information avaliable

Mexiletinum [INN-Latin] Molecular Weight

179.259 g/mol

Mexiletinum [INN-Latin] Melting Point

203-205 ^oC

Mexiletinum [INN-Latin] H₂O Solubility

8.25 mg/mL

Mexiletinum [INN-Latin] State

Solid

Mexiletinum [INN-Latin] LogP

2.039

Mexiletinum [INN-Latin] Dosage Forms

Capsule (150 mg, 200 mg and 250 mg)

Mexiletinum [INN-Latin] Indication

For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.

Mexiletinum [INN-Latin] Pharmacology

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine has fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.

Mexiletinum [INN-Latin] Absorption

Well absorbed (bioavailability 90%) from the gastrointenstinal tract.

Mexiletinum [INN-Latin] side effects and Toxicity

Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.

Mexiletinum [INN-Latin] Patient Information