Mexiletina [INN-Spanish]

Mexiletina [INN-Spanish] Brand names, Mexiletina [INN-Spanish] Analogs

Mexiletina [INN-Spanish] Brand Names Mixture

No information avaliable

Mexiletina [INN-Spanish] Chemical_Formula

C₁₁H₁₇NO

Mexiletina [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic3/mexiletine.htm

Mexiletina [INN-Spanish] fda sheet

Mexiletina_[INN-Spanish] FDA

Mexiletina [INN-Spanish] msds (material safety sheet)

Mexiletina_[INN-Spanish] MSDS

Mexiletina [INN-Spanish] Synthesis Reference

No information avaliable

Mexiletina [INN-Spanish] Molecular Weight

179.259 g/mol

Mexiletina [INN-Spanish] Melting Point

203-205 ^oC

Mexiletina [INN-Spanish] H₂O Solubility

8.25 mg/mL

Mexiletina [INN-Spanish] State

Solid

Mexiletina [INN-Spanish] LogP

2.039

Mexiletina [INN-Spanish] Dosage Forms

Capsule (150 mg, 200 mg and 250 mg)

Mexiletina [INN-Spanish] Indication

For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.

Mexiletina [INN-Spanish] Pharmacology

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine has fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.

Mexiletina [INN-Spanish] Absorption

Well absorbed (bioavailability 90%) from the gastrointenstinal tract.

Mexiletina [INN-Spanish] side effects and Toxicity

Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.

Mexiletina [INN-Spanish] Patient Information