Metubine
Metubine Brand names, Metubine Analogs
Metubine Brand Names Mixture
- No information avaliable
Metubine Chemical_Formula
C23H31NO7
Metubine RX_link
http://www.rxlist.com/cgi/generic3/cellcept.htm
Metubine fda sheet
Metubine msds (material safety sheet)
Metubine Synthesis Reference
No information avaliable
Metubine Molecular Weight
469.955 g/mol
Metubine Melting Point
No information avaliable
Metubine H2O Solubility
Slightly soluble (43 mg/mL at pH 7.4)
Metubine State
Solid
Metubine LogP
2.424
Metubine Dosage Forms
Capsule (250mg); Tablet (500 mg); Powder for solution (200 mg/mL constituted)
Metubine Indication
For the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. CellCept should be used concomitantly with cyclosporine and corticosteroids.
Metubine Pharmacology
Mycophenolate mofetil is a prodrug of mycophenolic acid, an antibiotic substance derived from Penicillium stoloniferum. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites.
Metubine Absorption
Rapidly absorbed following oral administration. In 12 healthy volunteers, the mean absolute bioavailability of oral mycophenolate mofetil relative to intravenous mycophenolate mofetil (based on MPA AUC) was 94%. Food (27 g fat, 650 calories) has no effect on the extent of absorption (MPA AUC) of mycophenolate mofetil.
Metubine side effects and Toxicity
Oral (LD50): Acute: 352 mg/kg [Rat], 1000 mg/kg [Mouse], and >6000 mg/kg [Rabbit]. Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.
Metubine Patient Information
No information avaliable
Metubine Organisms Affected
Humans and other mammals
