Dimetiltubocurarinio, ioduro de
Dimetiltubocurarinio, ioduro de Brand names, Dimetiltubocurarinio, ioduro de Analogs
Dimetiltubocurarinio, ioduro de Brand Names Mixture
- No information avaliable
Dimetiltubocurarinio, ioduro de Chemical_Formula
C23H31NO7
Dimetiltubocurarinio, ioduro de RX_link
http://www.rxlist.com/cgi/generic3/cellcept.htm
Dimetiltubocurarinio, ioduro de fda sheet
Dimetiltubocurarinio, ioduro de msds (material safety sheet)
Dimetiltubocurarinio, ioduro de Synthesis Reference
No information avaliable
Dimetiltubocurarinio, ioduro de Molecular Weight
469.955 g/mol
Dimetiltubocurarinio, ioduro de Melting Point
No information avaliable
Dimetiltubocurarinio, ioduro de H2O Solubility
Slightly soluble (43 mg/mL at pH 7.4)
Dimetiltubocurarinio, ioduro de State
Solid
Dimetiltubocurarinio, ioduro de LogP
2.424
Dimetiltubocurarinio, ioduro de Dosage Forms
Capsule (250mg); Tablet (500 mg); Powder for solution (200 mg/mL constituted)
Dimetiltubocurarinio, ioduro de Indication
For the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. CellCept should be used concomitantly with cyclosporine and corticosteroids.
Dimetiltubocurarinio, ioduro de Pharmacology
Mycophenolate mofetil is a prodrug of mycophenolic acid, an antibiotic substance derived from Penicillium stoloniferum. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites.
Dimetiltubocurarinio, ioduro de Absorption
Rapidly absorbed following oral administration. In 12 healthy volunteers, the mean absolute bioavailability of oral mycophenolate mofetil relative to intravenous mycophenolate mofetil (based on MPA AUC) was 94%. Food (27 g fat, 650 calories) has no effect on the extent of absorption (MPA AUC) of mycophenolate mofetil.
Dimetiltubocurarinio, ioduro de side effects and Toxicity
Oral (LD50): Acute: 352 mg/kg [Rat], 1000 mg/kg [Mouse], and >6000 mg/kg [Rabbit]. Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.
Dimetiltubocurarinio, ioduro de Patient Information
No information avaliable
Dimetiltubocurarinio, ioduro de Organisms Affected
Humans and other mammals
